Growth arrest–specific 2 protein family: Structure and function
نویسندگان
چکیده
منابع مشابه
The lipocalin protein family: structure and function.
The lipocalin protein family is a large group of small extracellular proteins. The family demonstrates great diversity at the sequence level; however, most lipocalins share three characteristic conserved sequence motifs, the kernel lipocalins, while a group of more divergent family members, the outlier lipocalins, share only one. Belying this sequence dissimilarity, lipocalin crystal structures...
متن کاملFundamental Characteristics of AAA+ Protein Family Structure and Function
Many complex cellular events depend on multiprotein complexes known as molecular machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to the generation of mechanical force. Members of the AAA+ ATPase superfamily (ATPases Associated with various cellular Activities) are critical components of many molecular machines. AAA+ proteins are defined by conserved modu...
متن کاملStructure-based function inference using protein family-specific fingerprints.
We describe a method to assign a protein structure to a functional family using family-specific fingerprints. Fingerprints represent amino acid packing patterns that occur in most members of a family but are rare in the background, a nonredundant subset of PDB; their information is additional to sequence alignments, sequence patterns, structural superposition, and active-site templates. Fingerp...
متن کاملStructure Based Identification of Protein Family Signatures for Function Annotation
2 Introduction Protein sequences are known to evolve much faster than structures. Pairs of distantly homologous proteins with very low sequence similarity may still share very similar folds and functions. One example of well-preserved structural motifs is given by specific three-dimensional orientations of amino acid residues in the active site of a protein, which are responsible for protein’s ...
متن کاملPolymerase delta interacting protein 2 sustains vascular structure and function.
OBJECTIVE On the basis of previous evidence that polymerase delta interacting protein 2 (Poldip2) increases reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (Nox4) activity in vascular smooth muscle cells, we hypothesized that in vivo knockdown of Poldip2 would inhibit reactive oxygen species production and alter vascular function. APPROACH AND RESULTS Because homozygous ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2020
ISSN: 0960-7722,1365-2184
DOI: 10.1111/cpr.12934